Open AccessMembranome 2.0: database for proteome-wide profiling of bitopic proteins and their dimers
Author(s) -
Andrei L. Lomize,
Jacob M. Hage,
Irina D. Pogozheva
Publication year - 2017
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btx720
Subject(s) - proteome , computational biology , membrane protein , transmembrane protein , chemistry , computer science , bioinformatics , biophysics , biology , membrane , biochemistry , receptor
Structural studies of TM domains of single-spanning (bitopic) membrane proteins are impeded by their instability, flexibility and heterogeneity. The new computational method TMDOCK allows reliable modeling of homodimers of transmembrane (TM) α-helices on a proteomic scale.
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