Predicting protein–DNA binding free energy change upon missense mutations using modified MM/PBSA approach: SAMPDI webserver | Zendy

Yunhui Peng | Zendy; Lexuan Sun | Zendy; Zhe Jia | Zendy; Lin Li | Zendy; Emil Alexov | Zendy

Open Access

Predicting protein–DNA binding free energy change upon missense mutations using modified MM/PBSA approach: SAMPDI webserver

Author(s) -

Yunhui Peng,

Lexuan Sun,

Zhe Jia,

Lin Li,

Emil Alexov

Publication year - 2017

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btx698

Subject(s) - dna , missense mutation , dna replication , mutation , computational biology , genetics , molecular mechanics , biology , protein data bank (rcsb pdb) , chemistry , gene , biochemistry , molecular dynamics , computational chemistry

Protein-DNA interactions are essential for regulating many cellular processes, such as transcription, replication, recombination and translation. Amino acid mutations occurring in DNA-binding proteins have profound effects on protein-DNA binding and are linked with many diseases. Hence, accurate and fast predictions of the effects of mutations on protein-DNA binding affinity are essential for understanding disease-causing mechanisms and guiding plausible treatments.

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