BetaSerpentine: a bioinformatics tool for reconstruction of amyloid structures | Zendy

Stanislav A. Bondarev | Zendy; Olga Bondareva | Zendy; Galina A. Zhouravleva | Zendy; Andrey V. Kajava | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

BetaSerpentine: a bioinformatics tool for reconstruction of amyloid structures

Author(s) -

Stanislav A. Bondarev,

Olga Bondareva,

Galina A. Zhouravleva,

Andrey V. Kajava

Publication year - 2017

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btx629

Subject(s) - structural bioinformatics , computer science , source code , computational biology , code (set theory) , bioinformatics , protein structure , artificial intelligence , algorithm , biology , programming language , biochemistry , set (abstract data type)

Numerous experimental studies have suggested that polypeptide chains of large amyloidogenic regions zig-zag in β-serpentine arrangements. These β-serpentines are stacked axially and form the superpleated β-structure. Despite this progress in the understanding of amyloid folds, the determination of their 3D structure at the atomic level is still a problem due to the polymorphism of these fibrils and incompleteness of experimental structural data. Today, the way to get insight into the atomic structure of amyloids is a combination of experimental studies with bioinformatics.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research