ZCCHC17 is a master regulator of synaptic gene expression in Alzheimer’s disease | Zendy

Zeljko Tomljanovic | Zendy; Mitesh Patel | Zendy; William Shin | Zendy; Andrea Califano | Zendy; Andrew F. Teich | Zendy

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ZCCHC17 is a master regulator of synaptic gene expression in Alzheimer’s disease

Author(s) -

Zeljko Tomljanovic,

Mitesh Patel,

William Shin,

Andrea Califano,

Andrew F. Teich

Publication year - 2017

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btx608

Subject(s) - gene expression , master regulator , regulator , gene , neuroscience , biology , regulation of gene expression , disease , gene regulatory network , computational biology , bioinformatics , genetics , transcription factor , pathology , medicine

In an effort to better understand the molecular drivers of synaptic and neurophysiologic dysfunction in Alzheimer's disease (AD), we analyzed neuronal gene expression data from human AD brain tissue to identify master regulators of synaptic gene expression.

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