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Sipros Ensemble improves database searching and filtering for complex metaproteomics
Author(s) -
Xuan Guo,
Zhou Li,
Qiuming Yao,
Ryan Mueller,
Jimmy K. Eng,
David L. Tabb,
William Judson Hervey,
Chongle Pan
Publication year - 2017
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btx601
Subject(s) - metaproteomics , computer science , comet , metagenomics , data mining , identification (biology) , scalability , database search engine , database , search engine , information retrieval , biology , biochemistry , gene , botany , astrobiology
Complex microbial communities can be characterized by metagenomics and metaproteomics. However, metagenome assemblies often generate enormous, and yet incomplete, protein databases, which undermines the identification of peptides and proteins in metaproteomics. This challenge calls for increased discrimination of true identifications from false identifications by database searching and filtering algorithms in metaproteomics.

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