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SNP genotyping and parameter estimation in polyploids using low-coverage sequencing data
Author(s) -
Paul D. Blischak,
Laura Kubatko,
Andrea D. Wolfe
Publication year - 2017
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btx587
Subject(s) - polyploid , biology , genotyping , population , inference , genotype , ploidy , computational biology , genetics , computer science , artificial intelligence , gene , demography , sociology
Genotyping and parameter estimation using high throughput sequencing data are everyday tasks for population geneticists, but methods developed for diploids are typically not applicable to polyploid taxa. This is due to their duplicated chromosomes, as well as the complex patterns of allelic exchange that often accompany whole genome duplication (WGD) events. For WGDs within a single lineage (autopolyploids), inbreeding can result from mixed mating and/or double reduction. For WGDs that involve hybridization (allopolyploids), alleles are typically inherited through independently segregating subgenomes.

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