CRISPR-RT: a web application for designing CRISPR-C2c2 crRNA with improved target specificity | Zendy

Houxiang Zhu | Zendy; Emily Richmond | Zendy; Chun Liang | Zendy

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CRISPR-RT: a web application for designing CRISPR-C2c2 crRNA with improved target specificity

Author(s) -

Houxiang Zhu,

Emily Richmond,

Chun Liang

Publication year - 2017

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btx580

Subject(s) - crispr , trans activating crrna , computational biology , computer science , genome editing , rna , cas9 , biology , guide rna , genetics , gene

CRISPR-Cas systems have been successfully applied in genome editing. Recently, the CRISPR-C2c2 system has been reported as a tool for RNA editing. Here we describe CRISPR-RT (CRISPR RNA-Targeting), the first web application to help biologists design crRNAs with improved target specificity for the CRISPR-C2c2 system. CRISPR-RT allows users to set up a wide range of parameters, making it highly flexible for current and future research in CRISPR-based RNA editing. CRISPR-RT covers major model organisms and can be easily extended to cover other species. CRISPR-RT will empower researchers in RNA editing.

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