CCFold: rapid and accurate prediction of coiled-coil structures and application to modelling intermediate filaments | Zendy

Dmytro Guzenko | Zendy; Sergei V. Strelkov | Zendy

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CCFold: rapid and accurate prediction of coiled-coil structures and application to modelling intermediate filaments

Author(s) -

Dmytro Guzenko,

Sergei V. Strelkov

Publication year - 2017

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btx551

Subject(s) - coiled coil , coiled tubing , computer science , protein structure prediction , intermediate filament , protein structure , physics , chemistry , biology , engineering , biophysics , mechanical engineering , nuclear magnetic resonance , cytoskeleton , biochemistry , cell

Accurate molecular structure of the protein dimer representing the elementary building block of intermediate filaments (IFs) is essential towards the understanding of the filament assembly, rationalizing their mechanical properties and explaining the effect of disease-related IF mutations. The dimer contains a ∼300-residue long α-helical coiled coil which cannot be assessed by either direct experimental structure determination or modelling using standard approaches. At the same time, coiled coils are well-represented in structural databases.

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