powsimR: power analysis for bulk and single cell RNA-seq experiments
Author(s) -
Beate Vieth,
Christoph Ziegenhain,
Swati Parekh,
Wolfgang Enard,
Ines Hellmann
Publication year - 2017
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btx435
Subject(s) - rna seq , computer science , power analysis , a priori and a posteriori , rna , power (physics) , r package , computational biology , data mining , software , gene , gene expression , biology , algorithm , genetics , transcriptome , computational science , programming language , philosophy , physics , epistemology , quantum mechanics , cryptography
Power analysis is essential to optimize the design of RNA-seq experiments and to assess and compare the power to detect differentially expressed genes in RNA-seq data. PowsimR is a flexible tool to simulate and evaluate differential expression from bulk and especially single-cell RNA-seq data making it suitable for a priori and posterior power analyses.
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