pqsfinder: an exhaustive and imperfection-tolerant search tool for potential quadruplex-forming sequences in R | Zendy

Jiří Hon | Zendy; Tomáš Martínek | Zendy; Jaroslav Zendulka | Zendy; Matej Lexa | Zendy

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pqsfinder: an exhaustive and imperfection-tolerant search tool for potential quadruplex-forming sequences in R

Author(s) -

Jiří Hon,

Tomáš Martínek,

Jaroslav Zendulka,

Matej Lexa

Publication year - 2017

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btx413

Subject(s) - bioconductor , repressor lexa , computer science , g quadruplex , computational biology , r package , indel , algorithm , testbed , range (aeronautics) , process (computing) , biology , dna , biological system , genetics , computational science , programming language , engineering , computer network , repressor , transcription factor , single nucleotide polymorphism , genotype , gene , aerospace engineering

G-quadruplexes (G4s) are one of the non-B DNA structures easily observed in vitro and assumed to form in vivo. The latest experiments with G4-specific antibodies and G4-unwinding helicase mutants confirm this conjecture. These four-stranded structures have also been shown to influence a range of molecular processes in cells. As G4s are intensively studied, it is often desirable to screen DNA sequences and pinpoint the precise locations where they might form.

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