Open AccessHUGIn: Hi-C Unifying Genomic Interrogator
Author(s) -
Joshua S. Martin,
Zheng Xu,
Alex P. Reiner,
Karen L. Mohlke,
Patrick F. Sullivan,
Bing Ren,
Ming Hu,
Yun Li
Publication year - 2017
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btx359
Subject(s) - chromatin , computational biology , genomics , functional genomics , biology , genome wide association study , genome , genetics , single nucleotide polymorphism , gene , genotype
High throughput chromatin conformation capture (3C) technologies, such as Hi-C and ChIA-PET, have the potential to elucidate the functional roles of non-coding variants. However, most of published genome-wide unbiased chromatin organization studies have used cultured cell lines, limiting their generalizability.
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