CWDPRNP: a tool for cervid prion sequence analysis in program R | Zendy

William L. Miller | Zendy; W. David Walter | Zendy

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CWDPRNP: a tool for cervid prion sequence analysis in program R

Author(s) -

William L. Miller,

W. David Walter

Publication year - 2017

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btx333

Subject(s) - chronic wasting disease , biology , genotype , genetics , prion protein , computational biology , disease , population , single nucleotide polymorphism , r package , gene , computer science , medicine , environmental health , scrapie , computational science , pathology

Chronic wasting disease is a fatal, neurological disease caused by an infectious prion protein, which affects economically and ecologically important members of the family Cervidae. Single nucleotide polymorphisms within the prion protein gene have been linked to differential susceptibility to the disease in many species. Wildlife managers are seeking to determine the frequencies of disease-associated alleles and genotypes and delineate spatial genetic patterns. The CWDPRNP package, implemented in program R, provides a unified framework for analyzing prion protein gene variability and spatial structure.

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