Evolutionary design of multiple genes encoding the same protein | Zendy

Goro Terai | Zendy; Satoshi Kamegai | Zendy; Akito Taneda | Zendy; Kiyoshi Asai | Zendy

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Evolutionary design of multiple genes encoding the same protein

Author(s) -

Goro Terai,

Satoshi Kamegai,

Akito Taneda,

Kiyoshi Asai

Publication year - 2017

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btx030

Subject(s) - gene , genome , computer science , computational biology , encoding (memory) , set (abstract data type) , codon usage bias , organism , coding (social sciences) , biology , genetics , programming language , artificial intelligence , mathematics , statistics

Enhancing expression levels of a target protein is an important goal in synthetic biology. A widely used strategy is to integrate multiple copies of genes encoding a target protein into a host organism genome. Integrating highly similar sequences, however, can induce homologous recombination between them, resulting in the ultimate reduction of the number of integrated genes.

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