DeuteRater: a tool for quantifying peptide isotope precision and kinetic proteomics | Zendy

Bradley C. Naylor | Zendy; Michael T Porter | Zendy; Elise Wilson | Zendy; Adam Herring | Zendy; Spencer Lofthouse | Zendy; Austin Hannemann | Zendy; Stephen Piccolo | Zendy; Alan L. Rockwood | Zendy; John C. Price | Zendy

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DeuteRater: a tool for quantifying peptide isotope precision and kinetic proteomics

Author(s) -

Bradley C. Naylor,

Michael T Porter,

Elise Wilson,

Adam Herring,

Spencer Lofthouse,

Austin Hannemann,

Stephen Piccolo,

Alan L. Rockwood,

John C. Price

Publication year - 2017

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btx009

Subject(s) - computer science , python (programming language) , software , workflow , proteome , source code , isotope , data mining , bioinformatics , database , biology , programming language , physics , quantum mechanics

Using mass spectrometry to measure the concentration and turnover of the individual proteins in a proteome, enables the calculation of individual synthesis and degradation rates for each protein. Software to analyze concentration is readily available, but software to analyze turnover is lacking. Data analysis workflows typically don't access the full breadth of information about instrument precision and accuracy that is present in each peptide isotopic envelope measurement. This method utilizes both isotope distribution and changes in neutromer spacing, which benefits the analysis of both concentration and turnover.

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