DACE: a scalable DP-means algorithm for clustering extremely large sequence data
Author(s) -
Linhao Jiang,
Yichao Dong,
Ning Chen,
Ting Chen
Publication year - 2016
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btw722
Subject(s) - cluster analysis , metagenomics , scalability , dna sequencing , computational biology , data mining , biology , gene , computer science , genetics , artificial intelligence , database
Advancements in next-generation sequencing technology have produced large amounts of reads at low cost in a short time. In metagenomics, 16S and 18S rRNA gene have been widely used as marker genes to profile diversity of microorganisms in environmental samples. Through clustering of sequencing reads we can determine both number of OTUs and their relative abundance. In many applications, clustering of very large sequencing data with high efficiency and accuracy is essential for downstream analysis.
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