HiLive: real-time mapping of illumina reads while sequencing | Zendy

Martin Lindner | Zendy; Benjamin Strauch | Zendy; Jakob M. Schulze | Zendy; Simon H. Tausch | Zendy; Piotr Wojciech Dąbrowski | Zendy; Andreas Nitsche | Zendy; Bernhard Y. Renard | Zendy

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HiLive: real-time mapping of illumina reads while sequencing

Author(s) -

Martin Lindner,

Benjamin Strauch,

Jakob M. Schulze,

Simon H. Tausch,

Piotr Wojciech Dąbrowski,

Andreas Nitsche,

Bernhard Y. Renard

Publication year - 2016

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btw659

Subject(s) - computer science , dna sequencer , source code , dna sequencing , software , illumina dye sequencing , data mining , operating system , dna , biology , genetics

Next Generation Sequencing is increasingly used in time critical, clinical applications. While read mapping algorithms have always been optimized for speed, they follow a sequential paradigm and only start after finishing of the sequencing run and conversion of files. Since Illumina machines write intermediate output results, HiLive performs read mapping while still sequencing and thereby drastically reduces crucial overall sample analysis time, e.g. in precision medicine.

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