BASIC: BCR assembly from single cells | Zendy

Stefan Canzar | Zendy; Karlynn E. Neu | Zendy; Qingming Tang | Zendy; Patrick C. Wilson | Zendy; Aly A. Khan | Zendy

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BASIC: BCR assembly from single cells

Author(s) -

Stefan Canzar,

Karlynn E. Neu,

Qingming Tang,

Patrick C. Wilson,

Aly A. Khan

Publication year - 2016

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btw631

Subject(s) - computational biology , single cell analysis , rna , sanger sequencing , biology , dna sequencing , single cell sequencing , rna seq , primer (cosmetics) , software , cell , computer science , dna , genetics , gene expression , gene , chemistry , transcriptome , organic chemistry , programming language , exome sequencing , mutation

The B-cell receptor enables individual B cells to identify diverse antigens, including bacterial and viral proteins. While advances in RNA-sequencing (RNA-seq) have enabled high throughput profiling of transcript expression in single cells, the unique task of assembling the full-length heavy and light chain sequences from single cell RNA-seq (scRNA-seq) in B cells has been largely unstudied.

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