RiboDiff: detecting changes of mRNA translation efficiency from ribosome footprints | Zendy

義夫 田中 | Zendy; Theofanis Karaletsos | Zendy; Philipp Drewe | Zendy; Vipin T. Sreedharan | Zendy; David Kuo | Zendy; Kamini Singh | Zendy; HansGuido Wendel | Zendy; Gunnar Rätsch | Zendy

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RiboDiff: detecting changes of mRNA translation efficiency from ribosome footprints

Author(s) -

義夫田中,

Theofanis Karaletsos,

Philipp Drewe,

Vipin T. Sreedharan,

David Kuo,

Kamini Singh,

HansGuido Wendel,

Gunnar Rätsch

Publication year - 2016

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btw585

Subject(s) - ribosome profiling , translation (biology) , computer science , ribosome , computational biology , preprocessor , messenger rna , data mining , biology , rna , artificial intelligence , gene , genetics

Deep sequencing based ribosome footprint profiling can provide novel insights into the regulatory mechanisms of protein translation. However, the observed ribosome profile is fundamentally confounded by transcriptional activity. In order to decipher principles of translation regulation, tools that can reliably detect changes in translation efficiency in case-control studies are needed.

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