Molecular mechanisms underlying COPD-muscle dysfunction unveiled through a systems medicine approach | Zendy

Igor Marín de Mas | Zendy; Éric Fanchon | Zendy; Balázs Papp | Zendy; Susana G. Kalko | Zendy; Josep Roca | Zendy; Marta Cascante | Zendy

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Molecular mechanisms underlying COPD-muscle dysfunction unveiled through a systems medicine approach

Author(s) -

Igor Marín de Mas,

Éric Fanchon,

Balázs Papp,

Susana G. Kalko,

Josep Roca,

Marta Cascante

Publication year - 2016

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btw566

Subject(s) - copd , skeletal muscle , medicine , bioinformatics , decipher , diabetes mellitus , biology , endocrinology

Skeletal muscle dysfunction is a systemic effect in one-third of patients with chronic obstructive pulmonary disease (COPD), characterized by high reactive-oxygen-species (ROS) production and abnormal endurance training-induced adaptive changes. However, the role of ROS in COPD remains unclear, not least because of the lack of appropriate tools to study multifactorial diseases.

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