Extensive complementarity between gene function prediction methods
Author(s) -
Vedrana Vidulin,
Tomislav Šmuc,
Fran Supek
Publication year - 2016
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btw532
Subject(s) - genome , computational biology , gene prediction , gene , function (biology) , annotation , gene ontology , complementarity (molecular biology) , biology , benchmark (surveying) , gene annotation , computer science , ranking (information retrieval) , data mining , genetics , machine learning , gene expression , geodesy , geography
The number of sequenced genomes rises steadily but we still lack the knowledge about the biological roles of many genes. Automated function prediction (AFP) is thus a necessity. We hypothesized that AFP approaches that draw on distinct genome features may be useful for predicting different types of gene functions, motivating a systematic analysis of the benefits gained by obtaining and integrating such predictions.
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