oxBS-MLE: an efficient method to estimate 5-methylcytosine and 5-hydroxymethylcytosine in paired bisulfite and oxidative bisulfite treated DNA | Zendy

Zongli Xu | Zendy; Jack A. Taylor | Zendy; YuetKin Leung | Zendy; ShukMei Ho | Zendy; Liang Niu | Zendy

Open Access

oxBS-MLE: an efficient method to estimate 5-methylcytosine and 5-hydroxymethylcytosine in paired bisulfite and oxidative bisulfite treated DNA

Author(s) -

Zongli Xu,

Jack A. Taylor,

YuetKin Leung,

ShukMei Ho,

Liang Niu

Publication year - 2016

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btw527

Subject(s) - bisulfite , 5 hydroxymethylcytosine , 5 methylcytosine , sodium bisulfite , dna , bisulfite sequencing , chemistry , dna methylation , biochemistry , gene , gene expression , organic chemistry

5-Methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are important epigenetic regulators of gene expression. 5mC and 5hmC levels can be computationally inferred at single base resolution using sequencing or array data from paired DNA samples that have undergone bisulfite and oxidative bisulfite conversion. Current estimation methods have been shown to produce irregular estimates of 5hmC level or are extremely computation intensive.

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