Optimization of signal-to-noise ratio for efficient microarray probe design | Zendy

O. V. Matveeva | Zendy; Yury D. Nechipurenko | Zendy; Evgeniy Riabenko | Zendy; Chikako Ragan | Zendy; Н.Н. Назипова | Zendy; Aleksey Y. Ogurtsov | Zendy; Svetlana A. Shabalina | Zendy

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Optimization of signal-to-noise ratio for efficient microarray probe design

Author(s) -

O. V. Matveeva,

Yury D. Nechipurenko,

Evgeniy Riabenko,

Chikako Ragan,

Н.Н. Назипова,

Aleksey Y. Ogurtsov,

Svetlana A. Shabalina

Publication year - 2016

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btw451

Subject(s) - comparative genomic hybridization , oligonucleotide , dna microarray , genome , nucleic acid thermodynamics , hybridization probe , dna–dna hybridization , biology , computational biology , genetics , microbiology and biotechnology , dna , gene , gene expression , base sequence

Target-specific hybridization depends on oligo-probe characteristics that improve hybridization specificity and minimize genome-wide cross-hybridization. Interplay between specific hybridization and genome-wide cross-hybridization has been insufficiently studied, despite its crucial role in efficient probe design and in data analysis.

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