Patterns of amino acid conservation in human and animal immunodeficiency viruses | Zendy

Olga S Voitenko | Zendy; Andi Dhroso | Zendy; Anna Feldmann | Zendy; Dmitry Korkin | Zendy; Olga Kalinina | Zendy

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Patterns of amino acid conservation in human and animal immunodeficiency viruses

Author(s) -

Olga S Voitenko,

Andi Dhroso,

Anna Feldmann,

Dmitry Korkin,

Olga Kalinina

Publication year - 2016

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btw441

Subject(s) - biology , conserved sequence , immunogenicity , nucleic acid , computational biology , protein–protein interaction , viral evolution , genetics , rna , virology , peptide sequence , antigen , gene

Due to their high genomic variability, RNA viruses and retroviruses present a unique opportunity for detailed study of molecular evolution. Lentiviruses, with HIV being a notable example, are one of the best studied viral groups: hundreds of thousands of sequences are available together with experimentally resolved three-dimensional structures for most viral proteins. In this work, we use these data to study specific patterns of evolution of the viral proteins, and their relationship to protein interactions and immunogenicity.

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