Efficient identification and analysis of chemical exchange in biomolecules by R1ρ relaxation dispersion with Amaterasu | Zendy

Erik Walinda | Zendy; Daichi Morimoto | Zendy; Mayu Nishizawa | Zendy; Masahiro Shirakawa | Zendy; Kenji Sugase | Zendy

Open Access

Efficient identification and analysis of chemical exchange in biomolecules by R1ρ relaxation dispersion with Amaterasu

Author(s) -

Erik Walinda,

Daichi Morimoto,

Mayu Nishizawa,

Masahiro Shirakawa,

Kenji Sugase

Publication year - 2016

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btw188

Subject(s) - biomolecule , relaxation (psychology) , dispersion (optics) , polarization (electrochemistry) , computer science , software , protocol (science) , biological system , analytical chemistry (journal) , nuclear magnetic resonance , chemistry , materials science , physics , nanotechnology , optics , chromatography , biology , medicine , psychology , social psychology , alternative medicine , pathology , programming language

We introduce here a novel acquisition and processing methodology for cross-polarization based 1D rotating-frame relaxation dispersion NMR experiments. This easy-to-use protocol greatly facilitates the screening, acquisition, processing and model fitting of large on- and off-resonance R1ρ relaxation dispersion NMR datasets in an automated manner for the analysis of chemical exchange phenomena in biomolecules.

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