Quantitative phosphoproteomics-based molecular network description for high-resolution kinase-substrate interactome analysis | Zendy

Yuta Narushima | Zendy; Hiroko KozukaHata | Zendy; Kouhei Tsumoto | Zendy; Junichiro Inoue | Zendy; Masaaki Oyama | Zendy

Open Access

Quantitative phosphoproteomics-based molecular network description for high-resolution kinase-substrate interactome analysis

Author(s) -

Yuta Narushima,

Hiroko KozukaHata,

Kouhei Tsumoto,

Junichiro Inoue,

Masaaki Oyama

Publication year - 2016

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btw164

Subject(s) - interactome , phosphoproteomics , computational biology , computer science , substrate (aquarium) , resolution (logic) , kinase , chemistry , biology , biochemistry , protein kinase a , artificial intelligence , gene , protein phosphorylation , ecology

Phosphorylation-dependent cellular signaling is known to play a diverse role in regulating multiple cellular processes such as proliferation, differentiation and apoptosis. Recent technological advances in mass spectrometry-based phosphoproteomics have enabled us to measure network-wide signaling dynamics in a comprehensive and quantitative manner. As conventional protein-protein interaction (PPI) information-based network analysis is insufficient to systematically analyze phosphorylation site-dependent complex interaction dynamics, here we develop and evaluate a platform to provide a high-resolution molecular network description for kinase-substrate interactome analysis.

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