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EBglmnet: a comprehensive R package for sparse generalized linear regression models
Author(s) -
Anhui Huang,
Dianting Liu
Publication year - 2016
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btw143
Subject(s) - elastic net regularization , lasso (programming language) , covariate , r package , computer science , prior probability , linear model , bayesian probability , sample size determination , linear regression , sample (material) , population , data mining , machine learning , statistics , artificial intelligence , mathematics , feature selection , computational science , chemistry , demography , chromatography , sociology , world wide web
EBglmnet is an R package implementing empirical Bayesian method with both lasso (EBlasso) and elastic net (EBEN) priors for generalized linear models. In our previous studies, both EBlasso and EBEN outperformed other state-of-the-art methods such as lasso and elastic net in inferring sparse genotype and phenotype associations, in which the number of covariates is typically much larger than the sample size. While high density genetic markers can be easily obtained nowadays in genetics and population analysis thanks to the advancements in molecular high throughput technologies, EBglmnet will be a very useful tool for statistical modeling in this area.

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