Open AccessComputational discovery of pathway-level genetic vulnerabilities in non-small-cell lung cancer
Author(s) -
Jonathan H. Young,
Michael Peyton,
Hyun Seok Kim,
Elizabeth A. McMillan,
John D. Minna,
Michael A. White,
Edward M. Marcotte
Publication year - 2016
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btw010
Subject(s) - computational biology , wnt signaling pathway , biology , drug discovery , bioinformatics , computer science , cancer research , genetics , gene
Novel approaches are needed for discovery of targeted therapies for non-small-cell lung cancer (NSCLC) that are specific to certain patients. Whole genome RNAi screening of lung cancer cell lines provides an ideal source for determining candidate drug targets.
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