MOGEN: a tool for reconstructing 3D models of genomes from chromosomal conformation capturing data | Zendy

Tuan Trieu | Zendy; Jianlin Cheng | Zendy

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MOGEN: a tool for reconstructing 3D models of genomes from chromosomal conformation capturing data

Author(s) -

Tuan Trieu,

Jianlin Cheng

Publication year - 2015

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btv754

Subject(s) - genome , chromosome , centromere , computational biology , chromosome conformation capture , biology , human genome , chromosomal rearrangement , genetics , gene , karyotype , gene expression , enhancer

The three-dimensional (3D) conformation of chromosomes and genomes play an important role in cellular processes such as gene regulation, DNA replication and genome methylation. Several methods have been developed to reconstruct 3D structures of individual chromosomes from chromosomal conformation capturing data such as Hi-C data. However, few methods can effectively reconstruct the 3D structures of an entire genome due to the difficulty of handling noisy and inconsistent inter-chromosomal contact data.

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