Computational identification of piRNA targets on mouse mRNAs | Zendy

Jiao Yuan | Zendy; Peng Zhang | Zendy; Ya Cui | Zendy; Jiajia Wang | Zendy; Geir Skogerbø | Zendy; Da-Wei Huang | Zendy; Runsheng Chen | Zendy; Shunmin He | Zendy

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Computational identification of piRNA targets on mouse mRNAs

Author(s) -

Jiao Yuan,

Peng Zhang,

Ya Cui,

Jiajia Wang,

Geir Skogerbø,

Da-Wei Huang,

Runsheng Chen,

Shunmin He

Publication year - 2015

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btv729

Subject(s) - piwi interacting rna , transposable element , biology , gene , computational biology , genetics , gene silencing , genome

PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that are highly abundant in the germline. One important role of piRNAs is to defend genome integrity by guiding PIWI proteins to silence transposable elements (TEs), which have a high potential to cause deleterious effects on their host. The mechanism of piRNA-mediated post-transcriptional silencing was also observed to affect mRNAs, suggesting that piRNAs might play a broad role in gene expression regulation. However, there has been no systematic report with regard to how many protein-coding genes might be targeted and regulated by piRNAs.

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