Identification of coupling DNA motif pairs on long-range chromatin interactions in human K562 cells | Zendy

KaChun Wong | Zendy; Yue Li | Zendy; Chengbin Peng | Zendy

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Identification of coupling DNA motif pairs on long-range chromatin interactions in human K562 cells

Author(s) -

KaChun Wong,

Yue Li,

Chengbin Peng

Publication year - 2015

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btv555

Subject(s) - chromatin , sequence motif , biology , enhancer , genetics , computational biology , dna , motif (music) , structural motif , gene , transcription factor , physics , biochemistry , acoustics

The protein-DNA interactions between transcription factors (TFs) and transcription factor binding sites (TFBSs, also known as DNA motifs) are critical activities in gene transcription. The identification of the DNA motifs is a vital task for downstream analysis. Unfortunately, the long-range coupling information between different DNA motifs is still lacking. To fill the void, as the first-of-its-kind study, we have identified the coupling DNA motif pairs on long-range chromatin interactions in human.

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