SeDuS: segmental duplication simulator | Zendy

Diego A. Hartasánchez | Zendy; Marina BrasóVives | Zendy; Juanma Fuentes-Díaz | Zendy; Oriol Vallès-Codina | Zendy; Arcadi Navarro | Zendy

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SeDuS: segmental duplication simulator

Author(s) -

Diego A. Hartasánchez,

Marina BrasóVives,

Juanma Fuentes-Díaz,

Oriol Vallès-Codina,

Arcadi Navarro

Publication year - 2015

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btv481

Subject(s) - executable , crossover , computer science , graphical user interface , interrupt , source code , interface (matter) , code (set theory) , operating system , programming language , artificial intelligence , embedded system , set (abstract data type) , bubble , maximum bubble pressure method , microcontroller

SeDuS is the first flexible and user-friendly forward-in-time simulator of patterns of molecular evolution within segmental duplications undergoing interlocus gene conversion and crossover. SeDuS introduces known features of interlocus gene conversion such as biased directionality and dependence on local sequence identity. Additionally, it includes aspects such as different selective pressures acting upon copy number and flexible crossover distributions. A graphical user interface allows fast fine-tuning of relevant parameters and straightforward real-time analysis of the evolution of duplicates.

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