Open AccessGeneration of sequence-based data for pedigree-segregating Mendelian or Complex traits
Author(s) -
Biao Li,
Gao T. Wang,
Suzanne M. Leal
Publication year - 2015
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btv412
Subject(s) - mendelian inheritance , sequence (biology) , genetics , biology , computational biology , computer science , gene
There is great interest in analyzing next generation sequence data that has been generated for pedigrees. However, unlike for population-based data there are only a limited number of rare variant methods to analyze pedigree data. One limitation is the ability to evaluate type I and II errors for family-based methods, due to lack of software that can simulate realistic sequence data for pedigrees.
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