IBiSS, a versatile and interactive tool for integrated sequence and 3D structure analysis of large macromolecular complexes | Zendy

Brice Beinsteiner | Zendy; Jonathan Michalon | Zendy; Bruno P. Klaholz | Zendy

Open Access

IBiSS, a versatile and interactive tool for integrated sequence and 3D structure analysis of large macromolecular complexes

Author(s) -

Brice Beinsteiner,

Jonathan Michalon,

Bruno P. Klaholz

Publication year - 2015

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btv347

Subject(s) - uniprot , protein data bank , ribosome , computational biology , protein data bank (rcsb pdb) , sequence (biology) , structural biology , cryo electron microscopy , sequence alignment , protein subunit , multiple sequence alignment , protein structure , computer science , biology , peptide sequence , crystallography , rna , chemistry , biochemistry , gene

In the past few years, an increasing number of crystal and cryo electron microscopy (cryo-EM) structures of large macromolecular complexes, such as the ribosome or the RNA polymerase, have become available from various species. These multi-subunit complexes can be difficult to analyze at the level of amino acid sequence in combination with the 3D structural organization of the complex. Therefore, novel tools for simultaneous analysis of structure and sequence information of complex assemblies are required to better understand the basis of molecular mechanisms and their functional implications.

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