DSigDB: drug signatures database for gene set analysis | Zendy

Minjae Yoo | Zendy; Jimin Shin | Zendy; Jihye Kim | Zendy; Karen A. Ryall | Zendy; Kyubum Lee | Zendy; Sunwon Lee | Zendy; Minji Jeon | Zendy; Jaewoo Kang | Zendy; Aik Choon Tan | Zendy

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DSigDB: drug signatures database for gene set analysis

Author(s) -

Minjae Yoo,

Jimin Shin,

Jihye Kim,

Karen A. Ryall,

Kyubum Lee,

Sunwon Lee,

Minji Jeon,

Jaewoo Kang,

Aik Choon Tan

Publication year - 2015

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btv313

Subject(s) - drug repositioning , repurposing , gene , resource (disambiguation) , set (abstract data type) , computer science , database , computational biology , drug , biology , genetics , pharmacology , programming language , ecology , computer network

We report the creation of Drug Signatures Database (DSigDB), a new gene set resource that relates drugs/compounds and their target genes, for gene set enrichment analysis (GSEA). DSigDB currently holds 22 527 gene sets, consists of 17 389 unique compounds covering 19 531 genes. We also developed an online DSigDB resource that allows users to search, view and download drugs/compounds and gene sets. DSigDB gene sets provide seamless integration to GSEA software for linking gene expressions with drugs/compounds for drug repurposing and translational research.

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