Genome-scale strain designs based on regulatory minimal cut sets | Zendy

Radhakrishnan Mahadevan | Zendy; Axel von Kamp | Zendy; Steffen Klamt | Zendy

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Genome-scale strain designs based on regulatory minimal cut sets

Author(s) -

Radhakrishnan Mahadevan,

Axel von Kamp,

Steffen Klamt

Publication year - 2015

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btv217

Subject(s) - constraint (computer aided design) , metabolic engineering , computer science , range (aeronautics) , set (abstract data type) , genome , matlab , flux (metallurgy) , strain (injury) , scale (ratio) , gene knockout , simple (philosophy) , key (lock) , theoretical computer science , mathematical optimization , gene , mathematics , biology , genetics , physics , chemistry , engineering , programming language , organic chemistry , anatomy , quantum mechanics , philosophy , geometry , epistemology , computer security , aerospace engineering

Stoichiometric and constraint-based methods of computational strain design have become an important tool for rational metabolic engineering. One of those relies on the concept of constrained minimal cut sets (cMCSs). However, as most other techniques, cMCSs may consider only reaction (or gene) knockouts to achieve a desired phenotype.

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