StructureFold: genome-wide RNA secondary structure mapping and reconstruction in vivo | Zendy

Yin Tang | Zendy; Dave Bouvier | Zendy; Chun Kit Kwok | Zendy; Yiliang Ding | Zendy; Anton Nekrutenko | Zendy; Philip C. Bevilacqua | Zendy; Sarah M. Assmann | Zendy

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StructureFold: genome-wide RNA secondary structure mapping and reconstruction in vivo

Author(s) -

Yin Tang,

Dave Bouvier,

Chun Kit Kwok,

Yiliang Ding,

Anton Nekrutenko,

Philip C. Bevilacqua,

Sarah M. Assmann

Publication year - 2015

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btv213

Subject(s) - rna , nucleic acid structure , computational biology , in silico , transcriptome , profiling (computer programming) , nucleic acid secondary structure , computer science , rna seq , biology , gene , gene expression , genetics , operating system

RNAs fold into complex structures that are integral to the diverse mechanisms underlying RNA regulation of gene expression. Recent development of transcriptome-wide RNA structure profiling through the application of structure-probing enzymes or chemicals combined with high-throughput sequencing has opened a new field that greatly expands the amount of in vitro and in vivo RNA structural information available. The resultant datasets provide the opportunity to investigate RNA structural information on a global scale. However, the analysis of high-throughput RNA structure profiling data requires considerable computational effort and expertise.

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