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Network prediction as applied to protein-protein interaction (PPI) networks has received considerable attention within the last decade. Because of the limitations of experimental techniques for interaction detection and network construction, several computational methods for PPI network reconstruction and growth have been suggested. Such methods usually limit the scope of study to a single network, employing data based on genomic context, structure, domain, sequence information or existing network topology. Incorporating multiple species network data for network reconstruction and growth entails the design of novel models encompassing both network reconstruction and network alignment, since the goal of network alignment is to provide functionally orthologous proteins from multiple networks and such orthology information can be used in guiding interolog transfers. However, such an approach raises the classical chicken or egg problem; alignment methods assume error-free networks, whereas network prediction via orthology works affectively if the functionally orthologous proteins are determined with high precision. Thus to resolve this intertwinement, we propose a framework to handle both problems simultaneously, that of SImultaneous Prediction and Alignment of Networks (SiPAN).

SiPAN: simultaneous prediction and alignment of protein–protein interaction networks