MUGBAS: a species free gene-based programme suite for post-GWAS analysis | Zendy

Stefano Capomaccio | Zendy; Marco Milanesi | Zendy; Lorenzo Bomba | Zendy; Elia Vajana | Zendy; Paolo AjmoneMarsan | Zendy

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MUGBAS: a species free gene-based programme suite for post-GWAS analysis

Author(s) -

Stefano Capomaccio,

Marco Milanesi,

Lorenzo Bomba,

Elia Vajana,

Paolo AjmoneMarsan

Publication year - 2015

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btv144

Subject(s) - suite , annotation , genome wide association study , computational biology , biology , gene , software , genetic association , software suite , genotype , genetics , computer science , single nucleotide polymorphism , programming language , geography , archaeology

Genome Wide Association Studies between molecular markers and phenotypes are now routinely run in model and non-model species. However, tools to estimate the probability of association of functional units (e.g. genes) containing multiple markers are not developed for species other than humans. Here we introduce MUGBAS (MUlti species Gene-Based Association Suite), software that estimates the P-value of a gene using information on annotation, single marker GWA results and genotype. The software is species and annotation independent, fast, highly parallelized and ready for high-density marker studies.

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