IVA: accurate de novo assembly of RNA virus genomes | Zendy

Martin Hunt | Zendy; Astrid Gall | Zendy; Swee Hoe Ong | Zendy; Jacqui Brener | Zendy; Bridget Ferns | Zendy; Philip Goulder | Zendy; Eleni Nastouli | Zendy; Jacqueline A. Keane | Zendy; Paul Kellam | Zendy; Thomas D. Otto | Zendy

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IVA: accurate de novo assembly of RNA virus genomes

Author(s) -

Martin Hunt,

Astrid Gall,

Swee Hoe Ong,

Jacqui Brener,

Bridget Ferns,

Philip Goulder,

Eleni Nastouli,

Jacqueline A. Keane,

Paul Kellam,

Thomas D. Otto

Publication year - 2015

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btv120

Subject(s) - genome , sequence assembly , computational biology , rna , virology , biology , virus , computer science , genetics , gene , gene expression , transcriptome

An accurate genome assembly from short read sequencing data is critical for downstream analysis, for example allowing investigation of variants within a sequenced population. However, assembling sequencing data from virus samples, especially RNA viruses, into a genome sequence is challenging due to the combination of viral population diversity and extremely uneven read depth caused by amplification bias in the inevitable reverse transcription and polymerase chain reaction amplification process of current methods.

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