Population-scale three-dimensional reconstruction and quantitative profiling of microglia arbors | Zendy

Murad Megjhani | Zendy; Nicolas Rey-Villamizar | Zendy; Amine Merouane | Zendy; Yanbin Lu | Zendy; Amit Mukherjee | Zendy; Kristen Trett | Zendy; Peter Chong | Zendy; Carolyn A. Harris | Zendy; William Shain | Zendy; Badrinath Roysam | Zendy

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Population-scale three-dimensional reconstruction and quantitative profiling of microglia arbors

Author(s) -

Murad Megjhani,

Nicolas Rey-Villamizar,

Amine Merouane,

Yanbin Lu,

Amit Mukherjee,

Kristen Trett,

Peter Chong,

Carolyn A. Harris,

William Shain,

Badrinath Roysam

Publication year - 2015

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btv109

Subject(s) - microglia , computer science , scalability , software , voxel , artificial intelligence , pattern recognition (psychology) , population , cluster analysis , neuroscience , computer vision , computational biology , biology , database , medicine , environmental health , immunology , inflammation , programming language

The arbor morphologies of brain microglia are important indicators of cell activation. This article fills the need for accurate, robust, adaptive and scalable methods for reconstructing 3-D microglial arbors and quantitatively mapping microglia activation states over extended brain tissue regions.

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