AIDA: ab initio domain assembly for automated multi-domain protein structure prediction and domain–domain interaction prediction | Zendy

Dong Xu | Zendy; Lukasz Jaroszewski | Zendy; Zhanwen Li | Zendy; Adam Godzik | Zendy

Open Access

AIDA: ab initio domain assembly for automated multi-domain protein structure prediction and domain–domain interaction prediction

Author(s) -

Dong Xu,

Lukasz Jaroszewski,

Zhanwen Li,

Adam Godzik

Publication year - 2015

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btv092

Subject(s) - domain (mathematical analysis) , computer science , protein structure prediction , template , benchmark (surveying) , protein domain , casp , folding (dsp implementation) , protein structure , ab initio , algorithm , data mining , chemistry , mathematics , programming language , mathematical analysis , biochemistry , geodesy , engineering , organic chemistry , electrical engineering , gene , geography

Most proteins consist of multiple domains, independent structural and evolutionary units that are often reshuffled in genomic rearrangements to form new protein architectures. Template-based modeling methods can often detect homologous templates for individual domains, but templates that could be used to model the entire query protein are often not available.

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