Open AccessClonality inference in multiple tumor samples using phylogeny
Author(s) -
Salem Malikić,
Andrew McPherson,
Nilgun Donmez,
Cenk S. Sahinalp
Publication year - 2015
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btv003
Subject(s) - phylogenetics , biology , phylogenetic tree , inference , in silico , computational biology , evolutionary biology , computer science , genetics , gene , artificial intelligence
Intra-tumor heterogeneity presents itself through the evolution of subclones during cancer progression. Although recent research suggests that this heterogeneity has clinical implications, in silico determination of the clonal subpopulations remains a challenge.
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