A logical model of HIV-1 interactions with the T-cell activation signalling pathway | Zendy

Oyebode James Oyeyemi | Zendy; O.W. Davies | Zendy; David L. Robertson | Zendy; JeanMarc Schwartz | Zendy

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A logical model of HIV-1 interactions with the T-cell activation signalling pathway

Author(s) -

Oyebode James Oyeyemi,

O.W. Davies,

David L. Robertson,

JeanMarc Schwartz

Publication year - 2014

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btu787

Subject(s) - in silico , signal transduction , biology , viral replication , computational biology , host (biology) , systems biology , microbiology and biotechnology , crosstalk , virus , gene , genetics , physics , optics

Human immunodeficiency virus type 1 (HIV-1) hijacks host cellular processes to replicate within its host. Through interactions with host proteins, it perturbs and interrupts signaling pathways that alter key cellular functions. Although networks of viral-host interactions have been relatively well characterized, the dynamics of the perturbation process is poorly understood. Dynamic models of infection have the potential to provide insights into the HIV-1 host interaction.

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