Open AccessOptimization method for obtaining nearest-neighbour DNA entropies and enthalpies directly from melting temperatures
Author(s) -
Gerald Weber
Publication year - 2014
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btu751
Subject(s) - nearest neighbour , melting temperature , dna , materials science , statistical physics , chemistry , thermodynamics , computer science , physics , artificial intelligence , biochemistry , composite material
Free energy nearest-neighbour (NN) thermodynamics is widely used in DNA biochemistry, ranging from the calculation of melting temperatures to the prediction of secondary structures. Methods to calculate NN parameters require the knowledge of total sequence entropies and enthalpies, which are not always available.
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