M3D: a kernel-based test for spatially correlated changes in methylation profiles | Zendy

Tom Mayo | Zendy; Gabriele Schweikert | Zendy; Guido Sanguinetti | Zendy

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M3D: a kernel-based test for spatially correlated changes in methylation profiles

Author(s) -

Tom Mayo,

Gabriele Schweikert,

Guido Sanguinetti

Publication year - 2014

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btu749

Subject(s) - kernel (algebra) , test (biology) , computer science , methylation , statistics , mathematics , biology , genetics , combinatorics , ecology , gene

DNA methylation is an intensely studied epigenetic mark implicated in many biological processes of direct clinical relevance. Although sequencing-based technologies are increasingly allowing high-resolution measurements of DNA methylation, statistical modelling of such data is still challenging. In particular, statistical identification of differentially methylated regions across different conditions poses unresolved challenges in accounting for spatial correlations within the statistical testing procedure.

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