Cosi2: an efficient simulator of exact and approximate coalescent with selection | Zendy

Ilya Shlyakhter | Zendy; Pardis C. Sabeti | Zendy; S. F. Schaffner | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Cosi2: an efficient simulator of exact and approximate coalescent with selection

Author(s) -

Ilya Shlyakhter,

Pardis C. Sabeti,

S. F. Schaffner

Publication year - 2014

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btu562

Subject(s) - coalescent theory , computer science , selection (genetic algorithm) , population , markov chain , markov process , algorithm , biology , mathematics , genetics , statistics , artificial intelligence , machine learning , demography , sociology , gene , phylogenetic tree

Efficient simulation of population genetic samples under a given demographic model is a prerequisite for many analyses. Coalescent theory provides an efficient framework for such simulations, but simulating longer regions and higher recombination rates remains challenging. Simulators based on a Markovian approximation to the coalescent scale well, but do not support simulation of selection. Gene conversion is not supported by any published coalescent simulators that support selection.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research