Trowel: a fast and accurate error correction module for Illumina sequencing reads | Zendy

EunCheon Lim | Zendy; Jonas Müller | Zendy; Jörg Hagmann | Zendy; Stefan R. Henz | Zendy; SangTae Kim | Zendy; Detlef Weigel | Zendy

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Trowel: a fast and accurate error correction module for Illumina sequencing reads

Author(s) -

EunCheon Lim,

Jonas Müller,

Jörg Hagmann,

Stefan R. Henz,

SangTae Kim,

Detlef Weigel

Publication year - 2014

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btu513

Subject(s) - computer science , illumina dye sequencing , dna sequencing , error detection and correction , software , base (topology) , computational biology , algorithm , dna , biology , genetics , mathematics , programming language , mathematical analysis

The ability to accurately read the order of nucleotides in DNA and RNA is fundamental for modern biology. Errors in next-generation sequencing can lead to many artifacts, from erroneous genome assemblies to mistaken inferences about RNA editing. Uneven coverage in datasets also contributes to false corrections.

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