Open AccessSystematic analysis of gene properties influencing organ system phenotypes in mammalian perturbations
Author(s) -
Ingo Vogt,
Jeanette Prinz,
Karolina Worf,
Mónica Campillos
Publication year - 2014
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btu487
Subject(s) - phenotype , gene , biology , genetics , gene regulatory network , systems biology , computational biology , transcription factor , regulation of gene expression , gene expression
Diseases and adverse drug reactions are frequently caused by disruptions in gene functionality. Gaining insight into the global system properties governing the relationships between genotype and phenotype is thus crucial to understand and interfere with perturbations in complex organisms such as diseases states.
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