Efficient initial volume determination from electron microscopy images of single particles | Zendy

Javier Vargas | Zendy; Ana-Lucia Álvarez-Cabrera | Zendy; R. Marabini | Zendy; J.M. Carazo | Zendy; Carlos Óscar S. Sorzano | Zendy

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Efficient initial volume determination from electron microscopy images of single particles

Author(s) -

Javier Vargas,

Ana-Lucia Álvarez-Cabrera,

R. Marabini,

J.M. Carazo,

Carlos Óscar S. Sorzano

Publication year - 2014

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btu404

Subject(s) - ransac , computer science , single particle analysis , volume (thermodynamics) , algorithm , noise (video) , a priori and a posteriori , orientation (vector space) , set (abstract data type) , artificial intelligence , mathematics , image (mathematics) , physics , philosophy , geometry , aerosol , epistemology , quantum mechanics , meteorology , programming language

Structural information of macromolecular complexes provides key insights into the way they carry out their biological functions. The reconstruction process leading to the final 3D map requires an approximate initial model. Generation of an initial model is still an open and challenging problem in single-particle analysis.

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