Structural and energetic determinants of tyrosylprotein sulfotransferase sulfation specificity | Zendy

Praveen Nedumpully-Govindan | Zendy; Lin Li | Zendy; Emil Alexov | Zendy; Mark Blenner | Zendy; Feng Ding | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Structural and energetic determinants of tyrosylprotein sulfotransferase sulfation specificity

Author(s) -

Praveen Nedumpully-Govindan,

Lin Li,

Emil Alexov,

Mark Blenner,

Feng Ding

Publication year - 2014

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btu309

Subject(s) - sulfation , biochemistry , chemistry , computational biology , peptide , tyrosine , biology

Tyrosine sulfation is a type of post-translational modification (PTM) catalyzed by tyrosylprotein sulfotransferases (TPST). The modification plays a crucial role in mediating protein-protein interactions in many biologically important processes. There is no well-defined sequence motif for TPST sulfation, and the underlying determinants of TPST sulfation specificity remains elusive. Here, we perform molecular modeling to uncover the structural and energetic determinants of TPST sulfation specificity.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research